Chromatography

HPLC/PDA Solution for identification of drugs in human urine

Toxicological analysis of body fluids is an important task whenever acute intoxications, abuse of drugs, or consumption of illicit drugs needs to be identified. Those analyses always require a lot of effort as a most universal sample pretreatment and identification method are called and has to be done as much as possible automated and fast. Prominence HPLC system with photodiodearray detection configured in a special solution system offer an identification based on retention time and the UV spectra of the component which is sufficient in most cases where toxic relevant concentrations are detected.

The system is based on common hardware modules using a special column switching procedure to enable sample pretreatment for urine samples with a cleaning step, rinsing to get rid of proteins and other urine components, transfer the sample onto the analytical columns and separation. Column selection valves for the analytical columns make it possible to use the system also for the analysis of blood / serum samples after a separate liquid/liquid extraction procedure. Detection and Identification are done with photodiodearray detector and library search and matches with UV spectra libraries.

• Based on prominence hardware modules and LC solution software
• Simple sample preparation
• Patented column switching and online extraction procedure
• Automated identification based on UV spectra and relative retention time